Hiring managers are interested in how self-aware you are, and whether or not you're willing to be open about what you bring to the table. A classic and unimpressive response to this question is disguising a strength as a weakness (e.g., "I work too hard"). Interviewers see right through insincere answers like this and you'll lose credibility as an applicant. Instead, respond with a realistic weakness relevant to the workplace, and be sure to follow up with positive ways you've gone about addressing your shortcoming to improve your work.
